BDBM50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190
SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
InChI Key InChIKey=DFCJPPDAOZROBS-FKWFRFQNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50034922
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 793nMAssay Description:effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 4 receptorMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.15E+3nMAssay Description:Displacement of [125I]NDP-MSH from Melanocortin 4 receptor at 10 uMMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 0.930nMAssay Description:Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assess...More data for this Ligand-Target Pair
Affinity DataEC50: 5.40nMAssay Description:Agonist activity at mouse melanocortin-4 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.60nMAssay Description:Agonist activity at mouse MC4 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 214nMAssay Description:Displacement of 125I-NDP-MSH from mouse MC4R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Displacement of Eu-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 2 hrs by time resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonistic activity evaluated at melanocortin 4 receptor (MC4R) of mouse HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 10.2nMAssay Description:Functional activity at the mouse melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 17.2nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-4 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 17.2nMAssay Description:Agonist activity to the mouse Melanocortin-4 receptor (mMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 10.7nMAssay Description:In vitro agonist potency for Mouse Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 2.28nMAssay Description:Agonist activity at mouse MC4R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKd: 5.01nMAssay Description:Antagonist activity at mouse MC4R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gen...More data for this Ligand-Target Pair
Affinity DataIC50: 121nMAssay Description:Displacement of [125I]-NDP-MSH from mouse MC4R expressed in HEK293 cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at mouse MC4R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataIC50: 359nMAssay Description:Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting analysisMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 548nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 290nMAssay Description:Agonist activity at human FLAG-tagged MC4R expressed in HTLA cells assessed as induction of beta-arrestin recruitment after 18 hrs by Presto-tango as...More data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Michigan Medical Center
Curated by ChEMBL
University Of Michigan Medical Center
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human FLAG-tagged MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 2 hrs by AlphaScr...More data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.5nMAssay Description:Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for ...More data for this Ligand-Target Pair